Serotonin and chronic hypoxic pulmonary hypertension activate a NADPH oxidase 4 and TRPM2 dependent pathway for pulmonary arterial smooth muscle cell proliferation and migration

Author:

Song Jia-Lin,Zheng Si-Yi,He Rui-Lan,Gui Long-Xin,Lin Mo-Jun,Sham James S.K.

Funder

Fujian Provincial Department of Science and Technology

National Natural Science Foundation of China

Publisher

Elsevier BV

Subject

Pharmacology,Molecular Medicine,Physiology

Reference77 articles.

1. Haemodynamic definitions and updated clinical classification of pulmonary hypertension;Simonneau;Eur. Respir. J.,2019

2. The principal pathways involved in the in vivo modulation of hypoxic pulmonary vasoconstriction, pulmonary arterial remodelling and pulmonary hypertension;Kylhammar;Acta Physiol. (Oxf.),2017

3. Induction of serotonin transporter by hypoxia in pulmonary vascular smooth muscle cells. Relationship with the mitogenic action of serotonin;Eddahibi;Circ. Res.,1999

4. Serotonin Transporter Overexpression is Responsible for Pulmonary Artery Smooth Muscle Hyperplasia in Primary Pulmonary Hypertension;Eddahibi,2001

5. Endothelin-1 and Serotonin are Involved in Activation of RhoA/Rho Kinase Signaling in the Chronically Hypoxic Hypertensive Rat Pulmonary Circulation;Homma,2007

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