Metamizol acts as an ATP sensitive potassium channel opener to inhibit the contracting response induced by angiotensin II but not to norepinephrine in rat thoracic aorta smooth muscle

Author:

Valenzuela Fermín,García-Saisó Sebastián,Lemini Cristina,Ramírez-Solares Rafael,Vidrio Horacio,Mendoza-Fernández Víctor

Publisher

Elsevier BV

Subject

Pharmacology,Molecular Medicine,Physiology

Reference19 articles.

1. Involvement of ATP-sensitive K+ channels in the peripheral antinociceptive effect induced by dipyrone;Alves;Eur. J. Pharmacol.,2002

2. The effect of a single intravenous dose of metamizol 2 g, ketorolac 30 mg and propacetamol 1 g on haemodynamic parameters and postoperative pain after heart surgery;Avellaneda;Eur. J. Anaesthesiol.,2000

3. ATP inhibits the synaptic release of acetylcholine in submucosal neurons;Barajas-Lopez;J. Pharmacol. Exp. Ther.,1995

4. K channel activation by nucleotide diphosphates and its inhibition by glibenclamide in vascular smooth muscle cells;Beech;Br. J. Pharmacol.,1993

5. Intravenous metamizol (dipyrone) in acute migraine treatment and in episodic tension-type headache—a placebo-controlled study;Bigal;Cephalalgia,2001

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