ADAM17 is the main sheddase for the generation of human triggering receptor expressed in myeloid cells (hTREM2) ectodomain and cleaves TREM2 after Histidine 157

Author:

Feuerbach Dominik,Schindler Patrick,Barske Carmen,Joller Stefanie,Beng-Louka Edwige,Worringer Katie A.,Kommineni Sravya,Kaykas Ajamete,Ho Daniel J.,Ye Chaoyang,Welzenbach Karl,Elain Gaelle,Klein Laurent,Brzak Irena,Mir Anis K.,Farady Christopher J.,Aichholz Reiner,Popp Simone,George Nathalie,Neumann Ulf

Publisher

Elsevier BV

Subject

General Neuroscience

Reference30 articles.

1. Apolipoprotein e is a ligand for triggering receptor expressed on myeloid cells 2 (TREM2);Atagi;J. Biol. Chem.,2015

2. The triggering receptor expressed on myeloid cells 2 binds apolipoprotein E;Bailey;J. Biol. Chem.,2015

3. A DAP12-mediated pathway regulates expression of CC chemokine receptor 7 and maturation of human dendritic cells;Bouchon;J. Exp. Med.,2001

4. Active-site determinants of substrate recognition by the metalloproteinases TACE and ADAM10;Caescu;Biochem. J,2009

5. Investigating the role of rare heterozygous TREM2 variants in Alzheimer's disease and frontotemporal dementia;Cuyvers;Neurobiol. Aging,2014

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