Clonidine as adjuvant for oxybuprocaine, bupivacaine or dextrorphan has a significant peripheral action in intensifying and prolonging analgesia in response to local dorsal cutaneous noxious pinprick in rats

Author:

Chen Yu-Wen,Chu Chin-Chen,Chen Yu-Chung,Hung Ching-Hsia,Hsueh Meng-I,Wang Jhi-Joung

Funder

National Science Council of Taiwan

Publisher

Elsevier BV

Subject

General Neuroscience

Reference27 articles.

1. Opiate- and alpha 2-adrenoceptor-induced hyperpolarizations of locus ceruleus neurons in brain slices: reversal by cyclic adenosine 3′:5′-monophosphate analogues;Andrade;J. Neurosci.,1985

2. Clonidine as an analgesic adjuvant to continuous paravertebral bupivacaine for post-thoracotomy pain;Bhatnagar;Anaesth. Intensive Care,2006

3. The alpha 2-adrenergic agonists clonidine and guanfacine produce tonic and phasic block of conduction in rat sciatic nerve fibers;Butterworth;Anesth. Analg.,1993

4. The spinal anaesthetic effect of dextromethorphan, dextrorphan, and 3-methoxymorphinan;Chen;Eur. J. Pharmacol.,2007

5. The dose-dependent study of verapamil and diltiazem on spinal anesthesia in the rat;Chen;Neurosci. Lett.,2010

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