Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance-Reference-Cited by-同舟云学术

Replacing the tropolonic methoxyl group of colchicine with methylamino increases tubulin binding affinity with improved therapeutic index and overcomes paclitaxel cross-resistance

Published:2023-05 Issue: Volume:68 Page:100951
ISSN:1368-7646
Container-title:Drug Resistance Updates
language:en
Short-container-title:Drug Resistance Updates

Author:

Yang Juanjuan,Song Dake,Li Bingqian,Gao Xiaoxiao,Wang Yuetong,Li Xiaohu,Bao Changshun,Wu Caijiao,Bao Yu,Waxman Samuel,Chen Guoliang,Jing Yongkui^ORCID

Funder

Shenyang Pharmaceutical University

Samuel Waxman Cancer Research Foundation

Publisher

Elsevier BV

Subject

Pharmacology (medical),Infectious Diseases,Cancer Research,Pharmacology,Oncology

Reference46 articles.

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4. Anti-mitotic activity of colchicine and the structural basis for its interaction with tubulin;Bhattacharyya;Med. Res. Rev.,2008

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