First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo-Reference-Cited by-同舟云学术

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First demonstration that brain CYP2D-mediated opiate metabolic activation alters analgesia in vivo

Published:2013-06 Issue:12 Volume:85 Page:1848-1855
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Zhou Kaidi,Khokhar Jibran Y.,Zhao Bin,Tyndale Rachel F.

Funder

Canadian Institutes of Health Research

National Institutes of Health

Centre for Addiction and Mental Health

Centre for Addiction and Mental Health Foundation, the Canada Foundation for Innovation

Ontario Ministry of Research and Innovation

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference53 articles.

1. Brain drug-metabolizing cytochrome P450 enzymes are active in vivo, demonstrated by mechanism-based enzyme inhibition;Miksys;Neuropsychopharmacology,2009

2. Regional and cellular induction of nicotine-metabolizing CYP2B1 in rat brain by chronic nicotine treatment;Miksys;Biochem Pharmacol,2000

3. Progress in psychiatry. 1;Michels;N Engl J Med,1993

4. Cytochrome P450 2D6: overview and update on pharmacology, genetics, biochemistry;Zanger;Naunyn-Schmiedeberg's Arch Pharmacol,2004

5. The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype;Gaedigk;Clin Pharmacol Ther,2008

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