Identification of cytochrome P450 2C18 and 2C76 in tree shrews: P450 2C18 effectively oxidizes typical human P450 2C9/2C19 chiral substrates warfarin and omeprazole with less stereoselectivity

Author:

Uno Yasuhiro,Minami Yuhki,Tsukiyama-Kohara Kyoko,Murayama Norie,Yamazaki HiroshiORCID

Funder

Japan Society for the Promotion of Science

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference35 articles.

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2. Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians;Shimada;J Pharmacol Exp Ther,1994

3. The human intestinal cytochrome P450 “pie”;Paine;Drug Metab Dispos,2006

4. Clinical relevance of genetic polymorphisms in the human CYP2C subfamily;Goldstein;Br J Clin Pharmacol,2001

5. Cytochrome P450 enzymes in drug metabolism: regulation of gene expression, enzyme activities, and impact of genetic variation;Zanger;Pharmacol Ther,2013

Cited by 1 articles. 订阅此论文施引文献 订阅此论文施引文献,注册后可以免费订阅5篇论文的施引文献,订阅后可以查看论文全部施引文献

1. Molecular and functional characterization of flavin-containing monooxygenases (FMO1–6) in tree shrews;Comparative Biochemistry and Physiology Part C: Toxicology & Pharmacology;2024-03

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