α4β2 neuronal nicotinic receptor positive allosteric modulation: An approach for improving the therapeutic index of α4β2 nAChR agonists in pain

Author:

Lee Chih-Hung,Zhu Chang,Malysz John,Campbell Thomas,Shaughnessy Thomas,Honore Prisca,Polakowski James,Gopalakrishnan Murali

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference19 articles.

1. Zhu C, Chin C-L, Rustay NR, Zhong C, Mikusa J, Chandran P, et al. Potentiation of analgesic efficacy but not side effects: co-administration of an α4β2 neuronal nicotinic acetylcholine receptor agonist and its positive allosteric modulator in experimental models of pain in rats. Biochem Pharmacol, submitted for publication.

2. The analgesic potential of compounds acting at acetylcholine receptors;Decker;Curr Top Med Chem,2004

3. Reduced nicotinic receptor-mediated antinociception following in vivo antisense knock-down in rat

4. Reduced antinociception in mice lacking neuronal nicotinic receptor subunits;Marubio;Nature,1999

5. Nicotinic regulation of calcium/calmodulin-dependent protein kinase II activation in the spinal cord;Damaj;J Pharmacol Exp Ther,2007

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