Inhibition of dipeptidyl peptidase IV by novel inhibitors with pyrazolidine scaffold

Author:

Cheon Hyae Gyeong,Kim Sung-Soo,Kim Kwang-Rok,Rhee Sang-Dal,Yang Sung-Don,Ahn Jin Hee,Park Sung-Dae,Lee Jae Mok,Jung Won Hoon,Lee Hye Sook,Kim Hee Youn

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference14 articles.

1. Minireview: the glucagon-like peptides;Drucker;Endocrinology,2001

2. Glucagon-like peptide 1 and inhibitors of dipeptidyl peptidase IV in the treatment of type 2 diabetes mellitus;Holst;Curr Opin Pharmacol,2004

3. Dipeptidyl-peptidase IV (CD26)-role in the inactivation of regulatory peptides;Mentlein;Regl Pept,1999

4. Dipeptidyl-peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon-like peptide-1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serum;Mentlein;Eur J Biochem,1993

5. Degradation of glucagon-like peptide-1 by human plasma in vitro yields an N-terminally truncated peptide that is a major endogenous metabolite in vivo;Deacon;J Clin Endocrinol Metab,1995

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