Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1-Reference-Cited by-同舟云学术

Evaluation of efficacy- versus affinity-driven agonism with biased GLP-1R ligands P5 and exendin-F1

Published:2021-08 Issue: Volume:190 Page:114656
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Marzook Amaara,Chen Shiqian,Pickford Phil,Lucey Maria,Wang Yifan,Corrêa Jr Ivan R.,Broichhagen Johannes,Hodson David J.,Salem Victoria,Rutter Guy A.,Tan Tricia M.,Bloom Stephen R.,Tomas Alejandra,Jones Ben

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference57 articles.

1. N.H. Cho, J.E. Shaw, S. Karuranga, Y. Huang, J.D. da Rocha Fernandes, A.W. Ohlrogge, et al., IDF Diabetes Atlas: Global estimates of diabetes prevalence for 2017 and projections for 2045, Diabetes Res. Clin. Pract. (2018). doi:10.1016/j.diabres.2018.02.023.

2. Type 2 diabetes: principles of pathogenesis and therapy;Stumvoll;Lancet,2005

3. Mechanisms of action and therapeutic application of glucagon-like peptide-1;Drucker;Cell Metab.,2018

4. Glucagon-like peptide 1 (GLP-1);Müller;Mol. Metab.,2019

5. Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas;Eng;J. Biol. Chem.,1992

Cited by 11 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Engineered mini-G proteins block the internalization of cognate GPCRs and disrupt downstream intracellular signaling;Science Signaling;2024-07-02

2. Distinct roles of the extracellular surface residues of glucagon-like peptide-1 receptor in β-arrestin 1/2 signaling;European Journal of Pharmacology;2024-04

3. The GLP-1R as a model for understanding and exploiting biased agonism in next-generation medicines;Journal of Endocrinology;2024-03-07

4. Abolishing β‐arrestin recruitment is necessary for the full metabolic benefits of G protein‐biased glucagon‐like peptide‐1 receptor agonists;Diabetes, Obesity and Metabolism;2023-10-05

5. Enhanced Endosomal Signaling and Desensitization of GLP-1R vs GIPR in Pancreatic Beta Cells;Endocrinology;2023-02-12