Clozapine bioactivation induces dose-dependent, drug-specific toxicity of human bone marrow stromal cells: A potential in vitro system for the study of agranulocytosis

Author:

Pereira Avril,Dean Brian

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference42 articles.

1. Clozapine treatment in Australia: a review of hematological monitoring;Copolov;Med J Aust,1998

2. Clozapine is oxidized by activated human neutrophils to a reactive nitrenium ion that irreversibly binds to the cells;Liu;J Pharmacol Exp Ther,1995

3. The metabolic formation of reactive intermediates from clozapine, a drug associated with agranulocytosis in man;Maggs;J Pharmacol Exp Ther,1995

4. A comparison of the oxidation of clozapine and olanzapine to reactive metabolites and the toxicity of these metabolites to human leukocytes;Gardner;Mol Pharmacol,1998

5. Mechanism of clozapine-induced agranulocytosis: current status of research and implications for drug development;Pirmohamed;CNS Drugs,1997

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