Rabbit 3-hydroxyhexobarbital dehydrogenase is a NADPH-preferring reductase with broad substrate specificity for ketosteroids, prostaglandin D2, and other endogenous and xenobiotic carbonyl compounds

Author:

Endo Satoshi,Matsunaga Toshiyuki,Matsumoto Atsuko,Arai Yuki,Ohno Satoshi,El-Kabbani Ossama,Tajima Kazuo,Bunai Yasuo,Yamano Shigeru,Hara Akira,Kitade Yukio

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference62 articles.

1. Oxidative metabolism of hexobarbital in human liver: relationship to polymorphic S-mephenytoin 4-hydroxylation;Knodell;J Pharmacol Exp Ther,1988

2. New aspects of hexobarbital metabolism: stereoselective metabolism, new metabolic pathway via GSH conjugation, and 3-hydroxyhexobarbital dehydrogenases;Takenoshita;Yakugaku Zasshi,2004

3. Stereoselective formation of glucuronides in metabolism of hexobarbital enantiomers in vivo: isolation and quantitation of glucuronides in rabbit urine;Miyano;Drug Metab Dispos,1981

4. Hexobarbital metabolism: a new metabolic pathway to produce 1,5-dimethylbarbituric acid and cyclohexenone-glutathione adduct via 3′-oxohexobarbital;Takenoshita;Xenobiotica,1993

5. Rabbit liver 3-hydroxyhexobarbital dehydrogenase. Purification and properties;Takenoshita;J Biol Chem,1974

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