Meclizine, a pregnane X receptor agonist, is a direct inhibitor and mechanism-based inactivator of human cytochrome P450 3A
Author:
Funder
National University of Singapore
Publisher
Elsevier BV
Subject
Pharmacology,Biochemistry
Reference55 articles.
1. Meclizine metabolism and pharmacokinetics: formulation on its absorption;Wang;J. Clin. Pharmacol.,2012
2. Meclizine is neuroprotective in models of Huntington’s disease;Gohil;Hum. Mol. Genet.,2011
3. Nutrient-sensitized screening for drugs that shift energy metabolism from mitochondrial respiration to glycolysis;Gohil;Nat. Biotechnol.,2010
4. Meclizine inhibits mitochondrial respiration through direct targeting of cytosolic phosphoethanolamine metabolism;Gohil;J. Biol. Chem.,2013
5. Meclozine promotes longitudinal skeletal growth in transgenic mice with achondroplasia carrying a gain-of-function mutation in the FGFR3 gene;Matsushita;Endocrinology,2015
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