The prototypic pharmacogenetic drug debrisoquine is a substrate of the genetically polymorphic organic cation transporter OCT1

Author:

Saadatmand Ali R.,Tadjerpisheh Sina,Brockmöller Jürgen,Tzvetkov Mladen V.

Funder

German Research Foundation (DFG)

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference51 articles.

1. Proceedings: a correlation between the response to debrisoquine and the amount of unchanged drug excreted in the urine;Angelo;Br J Pharmacol,1975

2. A family and population study of the genetic polymorphism of debrisoquine oxidation in a white British population;Evans;J Med Genet,1980

3. Polymorphic hydroxylation of debrisoquine in man;Mahgoub;Lancet,1977

4. Characterization of the common genetic defect in humans deficient in debrisoquine metabolism;Gonzalez;Nature,1988

5. The human debrisoquine 4-hydroxylase (CYP2D) locus: sequence and identification of the polymorphic CYP2D6 gene, a related gene, and a pseudogene;Kimura;Am J Hum Genet,1989

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