Corrector VX-809 promotes interactions between cytoplasmic loop one and the first nucleotide-binding domain of CFTR
Author:
Funder
Cystic Fibrosis Canada
Canadian Institutes for Health Research
Publisher
Elsevier BV
Subject
Pharmacology,Biochemistry
Reference45 articles.
1. CFTR function and prospects for therapy;Riordan;Annu. Rev. Biochem.,2008
2. Processing mutations disrupt interactions between the nucleotide binding and transmembrane domains of P-glycoprotein and the cystic fibrosis transmembrane conductance regulator (CFTR);Loo;J. Biol. Chem.,2008
3. The ΔF508 mutation disrupts packing of the transmembrane segments of the cystic fibrosis transmembrane conductance regulator;Chen;J. Biol. Chem.,2004
4. The cystic fibrosis V232D mutation inhibits CFTR maturation by disrupting a hydrophobic pocket rather than formation of aberrant interhelical hydrogen bonds;Loo;Biochem. Pharmacol.,2014
5. Revertants, low temperature, and correctors reveal the mechanism of F508del-CFTR rescue by VX-809 and suggest multiple agents for full correction;Farinha;Chem. Biol.,2013
Cited by 51 articles. 订阅此论文施引文献 订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献
1. ABC transporters involved in respiratory and cholestatic diseases: From rare to very rare monogenic diseases;Biochemical Pharmacology;2024-11
2. The Folding Pathway of ABC Transporter CFTR: Effective and Robust;Journal of Molecular Biology;2024-07
3. Functional Consequences of CFTR Interactions in Cystic Fibrosis;International Journal of Molecular Sciences;2024-03-16
4. Organic Synthesis and Current Understanding of the Mechanisms of CFTR Modulator Drugs Ivacaftor, Tezacaftor, and Elexacaftor;Molecules;2024-02-10
5. Post-approval studies with the CFTR modulators Elexacaftor-Tezacaftor—Ivacaftor;Frontiers in Pharmacology;2023-03-21
1.学者识别学者识别
2.学术分析学术分析
3.人才评估人才评估
"同舟云学术"是以全球学者为主线，采集、加工和组织学术论文而形成的新型学术文献查询和分析系统，可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容，当前同舟云学术共收录了国内外主流学术期刊6万余种，收集的期刊论文及会议论文总量共计约1.5亿篇，并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询！咨询电话：010-8811{复制后删除}0370
www.globalauthorid.com
TOP
Copyright © 2019-2024 北京同舟云网络信息技术有限公司 京公网安备11010802033243号 京ICP备18003416号-3