Pan-mTOR inhibitors sensitize the senolytic activity of navitoclax via mTORC2 inhibition-mediated apoptotic signaling-Reference-Cited by-同舟云学术

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Pan-mTOR inhibitors sensitize the senolytic activity of navitoclax via mTORC2 inhibition-mediated apoptotic signaling

Published:2022-06 Issue: Volume:200 Page:115045
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Xu Weitong,Zhao Tingting,Chen Honghan,Huang Ning,Gong Hui,Zhang Jian,Yang Yu,Li Tiepeng,Zhang Gongchang,Gong Chuhui,Yang Ming,Xiao Hengyi

Funder

National Natural Science Foundation of China

National Key Research and Development Program of China

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference60 articles.

1. The role of senescent cells in ageing;van Deursen;Nature,2014

2. Cellular senescence in aging and age-related disease: from mechanisms to therapy;Childs;Nat. Med.,2015

3. Cellular senescence and the senescent secretory phenotype in age-related chronic diseases;Zhu;Curr. Opin. Clin. Nutr. Metab. Care,2014

4. N. Ohtani, D.J. Mann, E.J.C.S. Hara, Cellular senescence: Its role in tumor suppression and aging 100 (2010) 792–797.

5. Cellular senescence mediates fibrotic pulmonary disease;Schafer;Nat. Commun.,2017

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1. mTORC2: A neglected player in aging regulation;Journal of Cellular Physiology;2024-07-10

2. Inhibitor PF-04691502 works as a senolytic to regulate cellular senescence;Experimental Gerontology;2024-02

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4. Researching New Drug Combinations with Senolytic Activity Using Senescent Human Lung Fibroblasts MRC-5 Cell Line;Pharmaceuticals;2024-01-04

5. Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies;aging and disease;2024

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