Crystal structures and mutagenesis of PPP-family ser/thr protein phosphatases elucidate the selectivity of cantharidin and novel norcantharidin-based inhibitors of PP5C

Author:

Chattopadhyay Debasish,Swingle Mark R.,Salter Edward A.,Wood Eric,D’Arcy Brandon,Zivanov Catherine,Abney Kevin,Musiyenko Alla,Rusin Scott F.,Kettenbach Arminja,Yet Larry,Schroeder Chad E.,Golden Jennifer E.,Dunham Wade H.,Gingras Anne-Claude,Banerjee Surajit,Forbes David,Wierzbicki Andrzej,Honkanen Richard E.ORCID

Funder

Abraham Mitchell Cancer Research Fund

Mayer Mitchell Annual Award for Excellence in Cancer Research

National Institute of Health Molecular Libraries Probe Production Centers Network (NIH/MLPCN)

American Cancer Society Research

NIH

Canadian Cancer Society Research Institute

Alabama Supercomputing Authority

DOE Office of Science by Argonne National Laboratory

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference66 articles.

1. Protein Ser/Thr/Tyr phosphorylation in the Archaea;Kennelly;J. Biol. Chem.,2014

2. Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin;Takai;FEBS Lett.,1987

3. Characterization of microcystin-LR, a potent inhibitor of type 1 and type 2A protein phosphatases;Honkanen;J. Biol. Chem.,1990

4. Cyanobacterial nodularin is a potent inhibitor of type 1 and type 2A protein phosphatases;Honkanen;Mol. Pharmacol.,1991

5. Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin;Suganuma;Cancer Res.,1990

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