P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a-Reference-Cited by-同舟云学术

P-glycoprotein deficiency enhances metabolic activation of and platelet response to clopidogrel through marked up-regulation of Cyp3a11 in mice: Direct evidence for the interplay between P-glycoprotein and Cyp3a

Published:2021-01 Issue: Volume:183 Page:114313
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Ji Jin-Zi,Li Yi-Fei^ORCID,Jiang Li-Ping^ORCID,Tai Ting,Ge Peng-Xin,Mi Qiong-Yu,Zhu Ting,Xie Hong-Guang^ORCID

Funder

National Natural Science Foundation of China

Natural Science Foundation of the Province of Jiangsu

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference44 articles.

1. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events;Bhatt;N. Engl. J. Med.,2006

2. 2016 ACC/AHA guideline focused update on duration of dual antiplatelet therapy in patients with coronary artery disease: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines;Levine;J. Am. Coll. Cardiol.,2016

3. Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite;Kazui;Drug Metab. Dispos.,2010

4. Individual variability in the disposition of and response to clopidogrel: pharmacogenomics and beyond;Xie;Pharmacol. Ther.,2011

5. Carboxylesterase 1 as a determinant of clopidogrel metabolism and activation;Zhu;J. Pharmacol. Exp. Ther.,2013

Cited by 9 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The metabolic activation of and platelet response to vicagrel vary with P-glycoprotein deficiency, rather than P-glycoprotein inhibition, in mice;Xenobiotica;2024-08-21

2. Role of circadian clock in the chronoefficacy and chronotoxicity of clopidogrel;British Journal of Pharmacology;2023-07-28

3. Enhanced metabolic activation of and platelet response to clopidogrel in T cell-deficient mice through induction of Cyp2c and Cyp3a and inhibition of Ces1;Journal of Thrombosis and Haemostasis;2023-05

4. Choline and trimethylamine N-oxide impair metabolic activation of and platelet response to clopidogrel through activation of the NOX/ROS/Nrf2/CES1 pathway;Journal of Thrombosis and Haemostasis;2023-01

5. Effect of CYP4F2 Polymorphisms on Ticagrelor Pharmacokinetics in Healthy Chinese Volunteers;Frontiers in Pharmacology;2022-02-25