Mechanisms of tolvaptan-induced toxicity in HepG2 cells

Author:

Wu Yuanfeng,Beland Frederick A.,Chen Si,Liu Fang,Guo Lei,Fang Jia-Long

Funder

U.S. Department of Energy

FDA

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference65 articles.

1. Hyponatremia in critical care patients: frequency, outcome, characteristics, and treatment with the vasopressin V2-receptor antagonist tolvaptan;Friedman;J. Crit. Care,2013

2. Tolvaptan, a selective oral vasopressin V2-receptor antagonist, for hyponatremia;Schrier;N. Engl. J. Med.,2006

3. Tolvaptan in patients with autosomal dominant polycystic kidney disease;Torres;N. Engl. J. Med.,2012

4. Effect of grapefruit juice on the pharmacokinetics of tolvaptan, a non-peptide arginine vasopressin antagonist, in healthy subjects;Shoaf;Eur. J. Clin. Pharmacol.,2012

5. Effects of CYP3A4 inhibition and induction on the pharmacokinetics and pharmacodynamics of tolvaptan, a non-peptide AVP antagonist in healthy subjects;Shoaf;Br. J. Clin. Pharmacol.,2012

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