BRP-187: A potent inhibitor of leukotriene biosynthesis that acts through impeding the dynamic 5-lipoxygenase/5-lipoxygenase-activating protein (FLAP) complex assembly

Author:

Garscha Ulrike,Voelker Susanna,Pace Simona,Gerstmeier Jana,Emini Besa,Liening Stefanie,Rossi Antonietta,Weinigel Christina,Rummler Silke,Schubert Ulrich S.,Scriba Gerhard K.E.,Çelikoğlu Erşan,Çalışkan Burcu,Banoglu Erden,Sautebin Lidia,Werz Oliver

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference58 articles.

1. Leukotrienes;Peters-Golden;N. Engl. J. Med.,2007

2. 5-Lipoxygenase, a key enzyme for leukotriene biosynthesis in health and disease;Radmark;Biochim. Biophys. Acta,1851

3. 5-Lipoxygenase inhibitors: a review of recent developments and patents;Pergola;Expert Opin. Ther. Pat.,2010

4. Modulation of inflammatory disease by inhibitors of leukotriene A4 hydrolase;Fourie;Curr. Opin. Investig. Drugs,2009

5. Tandem benzophenone amino pyridines, potent and selective inhibitors of human leukotriene C4 synthase;Kleinschmidt;J. Pharmacol. Exp. Ther.,2015

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