The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4-Reference-Cited by-同舟云学术

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The antiandrogen flutamide is a novel aryl hydrocarbon receptor ligand that disrupts bile acid homeostasis in mice through induction of Abcc4

Published:2016-11 Issue: Volume:119 Page:93-104
ISSN:0006-2952
Container-title:Biochemical Pharmacology
language:en
Short-container-title:Biochemical Pharmacology

Author:

Gao Xiaoxia,Xie Cen,Wang Yuanyuan,Luo Yuhong,Yagai Tomoki,Sun Dongxue,Qin Xuemei,Krausz Kristopher W.,Gonzalez Frank J.

Funder

National Cancer Institute Intramural Research Program

National Natural Science Foundation of China

Shanxi University

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference47 articles.

1. Flutamide hepatotoxicity;Wysowski;J. Urol.,1996

2. Spontaneous reporting of hepatotoxicity associated with antiandrogens: data from the Spanish pharmacovigilance system;Manso;Pharmacoepidemiol. Drug Saf.,2006

3. Hepatotoxicity induced by antiandrogens: a review of the literature;Thole;Urol. Int.,2004

4. Covalent binding and tissue distribution/retention assessment of drugs associated with idiosyncratic drug toxicity;Takakusa;Drug Metab. Dispos.,2008

5. K.J. Coe, Metabolism and Cytotoxicity of the Nitroaromatic Drug Flutamide and Its Cyano Analog in Hepatocyte Cell Lines, ProQuest2008.

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