PM060184, a new tubulin binding agent with potent antitumor activity including P-glycoprotein over-expressing tumors

Author:

Martínez-Díez Marta,Guillén-Navarro María José,Pera Benet,Bouchet Benjamin Pierre,Martínez-Leal Juan Fernando,Barasoain Isabel,Cuevas Carmen,Andreu Jose M.,García-Fernández Luis Francisco,Díaz J. Fernando,Avilés Pablo,Galmarini Carlos M.

Funder

BIO2010-16351

CAM S2010/BMD-2457

CAM S2010/BMD-2353

BFU2011-23416

PharmaMar-CSIC

Comunidad de Madrid

Publisher

Elsevier BV

Subject

Pharmacology,Biochemistry

Reference50 articles.

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2. Microtubule treadmilling: what goes around comes around;Margolis;Bioessays,1998

3. Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death;Jordan;Cancer Res,1996

4. Mitosis is not a key target of microtubule agents in patient tumors;Komlodi-Pasztor;Nat Rev Clin Oncol,2011

5. How do microtubule-targeted drugs work? An overview;Jordan;Curr Cancer Drug Targets,2007

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