Hot spots in protein–protein interfaces: Towards drug discovery

Author:

Cukuroglu Engin,Engin H. Billur,Gursoy Attila,Keskin Ozlem

Publisher

Elsevier BV

Subject

Molecular Biology,Biophysics

Reference112 articles.

1. Acuner-Ozbabacan, S.E., Engin, H.B., Guven-Maiorov, E., Kuzu, G., Muratcioglu, S., Baspinar, A., Chen, Z., Van Waes, C., Gursoy, A., Keskin, O. and Nussinov, R. The Network of Interleukin-10 Protein Structural Interactions with Other Signaling Molecules and Its Implications in Inflammation and Cancer, BMC Genomics.

2. The structural pathway of interleukin 1 (IL-1) initiated signaling reveals mechanisms of oncogenic mutations and SNPs in inflammation and cancer;Acuner Ozbabacan;PLoS Comput Biol.,2014

3. Characterizing changes in the rate of protein-protein dissociation upon interface mutation using hotspot energy and organization;Agius;PLoS Comput Biol.,2013

4. Binding of small molecules to an adaptive protein-protein interface;Arkin;Proc. Natl. Acad. Sci. U. S. A.,2003

5. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream;Arkin;Nat. Rev. Drug. Discov.,2004

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