A new model for embryotoxicity testing: teratogenicity and pharmacokinetics of valproic acid following constant-rate administration in the mouse using human therapeutic drug and metabolite concentrations

Author:

Nau H.,Zierer R.,Spielmann H.,Neubert D.,Gansau Ch.

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference19 articles.

1. Clinical Pharmacokinetics of Valproic Acid1

2. Valproic acid dosage and plasma protein binding and clearance

3. Epilepsy Pregnancy and the Child;Nau,1981

4. Proceedings of the Fourth International Conference on Stable Isotopes;Wittfoht,1981

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3. The North American Antiepileptic Drug Pregnancy Registry: A Canadian Subgroup Analysis;Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques;2022-01-13

4. Modified Xenopus laevis approach (R-FETAX) as an alternative test for the evaluation of foetal valproate spectrum disorder;Reproductive Toxicology;2022-01

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