The antitumour activity of alkylating agents is not correlated with the levels of glutathione, glutathione transferase and O6-alkylguanine-DNA-alkyltransferase of human tumour xenografts

Author:

D’Incalci M,Bonfanti M,Pifferi A,Mascellani E,Tagliabue G,Berger D,Fiebig H.H

Publisher

Elsevier BV

Subject

Cancer Research,Oncology

Reference46 articles.

1. Importance of the DNA repair enzyme O6-alkyl guanine alkyltransferase (AT) in cancer chemotherapy;D’Incalci;Cancer Treat Rev,1988

2. Mammalian O6-alkylguanine-DNA alkyltransferase: regulation and importance in response to alkylating carcinogenic and therapeutic agents;Pegg;Cancer Res,1990

3. DNA repair in eukaryotes;Wood;Annu Rev Biochem,1996

4. DNA cross-linking and monoadduct repair in nitrosourea-treated human tumour cells;Erickson;Nature,1980

5. O6-Alkylguanine-DNA alkyltransferase activity correlates with the therapeutic response of human rhabdomyosarcoma xenografts to 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea;Brent;Proc Natl Acad Sci USA,1985

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