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Keto acid metabolites of branched-chain amino acids inhibit oxidative stress-induced necrosis and attenuate myocardial ischemia–reperfusion injury

  • Published:2016-12 Issue: Volume:101 Page:90-98
  • ISSN:0022-2828
  • Container-title:Journal of Molecular and Cellular Cardiology
  • language:en
  • Short-container-title:Journal of Molecular and Cellular Cardiology

Author:

Dong Weibing,Zhou Meiyi,Dong Mei,Pan Bangfen,Liu Yunxia,Shao Jing,Gu Xiaoping,Huang Ying,Li Guangping,Wang Yibin,Sun Haipeng

Funder

Ministry of Science and Technology of China Grant

National Institute of Health

Laubisch Fund (UCLA)

American Heart Association (AHA) Science Development Grant

AHA Established Investigator Award

National Natural Science Foundation of China

Science and Technology Commission of Shanghai Municipality

Publisher

Elsevier BV

Subject

Cardiology and Cardiovascular Medicine,Molecular Biology

Reference41 articles.

1. Branched-chain amino acids in metabolic signalling and insulin resistance;Lynch;Nat. Rev. Endocrinol.,2014

2. Catabolic defect of branched-chain amino acids promotes heart failure;Sun;Circulation,2016

3. Defective branched chain amino acids catabolism contributes to cardiac dysfunction and remodeling following myocardial infarction;Wang;Am. J. Physiol. Heart Circ. Physiol.,2016

4. BCKA down-regulates mTORC2-Akt signal and enhances apoptosis susceptibility in cardiomyocytes;Guo;Biochem. Biophys. Res. Commun.,2016

5. Inhibition of brain energy metabolism by the [alpha]-keto acids accumulating in maple syrup urine disease;Sgaravatti;BBA-Mol. Basis Dis.,1639
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