NMR and DFT analysis of the major diastereomeric degradation product of clopidogrel under oxidative stress conditions
Author:
Funder
Leibniz-Gemeinschaft
Publisher
Elsevier BV
Subject
Inorganic Chemistry,Organic Chemistry,Spectroscopy,Analytical Chemistry
Reference37 articles.
1. Clopidogrel, A Novel Antiplatelet and Antithrombotic Agent
2. For some recent studies about clopidogrel in medicine, see: (a) G.U. Kim, S. Lee, J. Choe, et al. Risk of postpolypectomy bleeding in patients taking direct oral anticoagulants or clopidogrel. Sci Rep 11 (2021) 2634-2641 doi:10.1038/s41598-021-82251-y
3. (b) K. Huynh, Clopidogrel is a favourable alternative to ticagrelor in older patients with NSTE-ACS. Nat Rev Cardiol 17 (2020) 384-384 doi:10.1038/s41569-020-0393-9.
4. Developments in the synthesis of the antiplatelet and antithrombotic drug (S)-clopidogrel
5. For some recent studies about clopidogrel in pharmaceutical and medicinal chemistry, see: (a) Y. Zhu, E.L. Romero, X. Ren, et al. Clopidogrel as a donor probe and thioenol derivatives as flexible promoieties for enabling H2S biomedicine. Nat Commun 9 (2018) 3952 doi:10.1038/s41467-018-06373-0
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1. Mechanochemical Oxidative Degradation of Thienopyridine Containing Drugs: Toward a Simple Tool for the Prediction of Drug Stability;ACS Central Science;2023-05-16
2. Selective Oxidation of Clopidogrel by Peroxymonosulfate (PMS) and Sodium Halide (NaX) System: An NMR Study;Molecules;2021-09-29
3. Ball milling – a new concept for predicting degradation profiles in active pharmaceutical ingredients;Chemical Communications;2021
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