X-ray crystal structure of a 2-amino-3,4-dihydroquinazoline 5-HT3 serotonin receptor antagonist and related analogs

Author:

Abdelkhalek Ahmed S.,Musayev Faik N.,Iyer Kavita A.,Hemanth Prithvi,Safo Martin K.ORCID,Dukat MałgorzataORCID

Funder

Egyptian Cultural and Educational Bureau

VCU

NIH

Publisher

Elsevier BV

Subject

Inorganic Chemistry,Organic Chemistry,Spectroscopy,Analytical Chemistry

Reference11 articles.

1. 2-Amino-6-chloro-3,4-dihydroquinazoline: a novel 5-HT3 receptor antagonist with antidepressant character;Dukat;Bioorg. Med. Chem. Lett,2013

2. “Methylene bridge” to 5-HT3 receptor antagonists: conformationally constrained phenylguanidines;Abdelkhalek;ACS Chem. Neurosci.,2019

3. Typical interatomic distances: organic compounds;Allen,2006

4. 2,6-Dichlorophenylguanidinium chloride;Barker;Acta Crystallogr.,1995

5. Cyclic guanidines as dual 5-HT5A/5-HT7 receptor ligands: optimising brain penetration;Peters;Bioorg. Med. Chem. Lett,2008

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