Protocol and statistical analysis plan for the mega randomised registry trial comparing conservative vs. liberal oxygenation targets in adults with nonhypoxic ischaemic acute brain injuries and conditions in the intensive care unit (Mega-ROX Brains)

Author:

Young Paul J.,Al-Fares Abdulrahman,Aryal Diptesh,Arabi Yaseen M.,Ashraf Muhammad Sheharyar,Bagshaw Sean M.,Mat-Nor Mohd Basri,Beane Abigail,Borghi Giovanni,de Oliveira Manoel Airton L.,Dullawe Layoni,Fazla Fathima,Fujii Tomoko,Haniffa Rashan,Hodgson Carol L.,Hunt Anna,Lawrence Cassie,Mackle Diane,Mangal Kishore,Nichol Alistair D.,Olatunji Shaanti,Rashan Aasiyah,Rashan Sumayyah,Tomazini Bruno,Kasza Jessica

Publisher

Elsevier BV

Subject

Anesthesiology and Pain Medicine,Critical Care and Intensive Care Medicine,Emergency Medicine

Reference16 articles.

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2. Predicting intracranial pressure and brain tissue oxygen crises in patients with severe traumatic brain injury;Myers;Crit Care Med,2016

3. Reduced brain tissue oxygen in traumatic brain injury: are most commonly used interventions successful?;Pascual;J Trauma,2011

4. Normobaric hyperoxia is associated with increased cerebral excitotoxicity after severe traumatic brain injury;Quintard;Neurocrit Care,2015

5. Hyperoxemia and cerebral vasospasm in Aneurysmal subarachnoid Hemorrhage;Reynolds;Neurocrit Care,2021

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