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Elucidating the role of free polycations in gene knockdown by siRNA polyplexes

  • Published:2016-04 Issue: Volume:35 Page:248-259
  • ISSN:1742-7061
  • Container-title:Acta Biomaterialia
  • language:en
  • Short-container-title:Acta Biomaterialia

Author:

Klauber Thomas C.B.,Søndergaard Rikke V.,Sawant Rupa R.,Torchilin Vladimir P.,Andresen Thomas L.

Funder

Danish Council for Strategic Research

Technical University of Denmark

Publisher

Elsevier BV

Subject

Molecular Biology,Biomedical Engineering,Biochemistry,Biomaterials,General Medicine,Biotechnology

Reference51 articles.

1. siRNA therapeutics: big potential from small RNAs;Ryther;Gene Ther.,2005

2. Knocking down barriers: advances in siRNA delivery;Whitehead;Nat. Rev. Drug Discov.,2009

3. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals;Zamore;Cell,2000

4. RNA interference is mediated by 21- and 22-nucleotide RNAs;Elbashir;Genes Dev.,2001

5. Evidence of RNAi in humans from systemically administered siRNA via targeted nanoparticles;Davis;Nature,2010
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