A diastereoselective synthesis of 7α-nitromethyl steroid derivative and its use for an efficient synthesis of eplerenone

Author:

Zhang Bin,Chen Hongli,Tang Huanyu,Feng Huijin,Li Yuanchao

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Pharmacology,Endocrinology,Molecular Biology,Biochemistry

Reference18 articles.

1. Process to prepare eplerenone and its intermediates from delta 9-canrenone and other pregnanes;Pearlman,2003

2. Stereoselective synthesis of 6β,7β -methylene-3-oxo-17α -pregn-4-ene-21,17-carbolactone;Nickisch;Tetrahedron Lett,1981

3. Synthesis of 6β,7β-nitromethylene steroids;Shapiro;Tetrahedron Lett,1977

4. Novel transformation of primary nitroalkanes and primary alkyl bromides to the corresponding carboxylic acids;Matt;J Org Chem,1997

5. Bifunctional-thiourea-catalyzed diastereo- and enantioselective aza-Henry reaction;Xu;Chem Eur J,2006

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