Synthesis of antiproliferative 13α-d-homoestrones via Lewis acid-promoted one-pot Prins–Ritter reactions of d-secosteroidal δ-alkenyl-aldehydes

Author:

Huber Judit,Wölfling János,Schneider Gyula,Ocsovszki Imre,Varga Mónika,Zupkó István,Mernyák Erzsébet

Funder

Hungarian Scientific Research Fund

European Union

European Social Fund

Publisher

Elsevier BV

Subject

Organic Chemistry,Clinical Biochemistry,Pharmacology,Endocrinology,Molecular Biology,Biochemistry

Reference28 articles.

1. Synthesis and receptor-binding examinations of the normal and 13-epi-d-homoestrones and their 3-methyl ethers;Wölfling;Steroids,2003

2. Antiproliferative effect of normal and 13-epi-d-homoestrone and their 3-methyl ethers on human reproductive cancer cell lines;Minorics;J. Steroid Biochem. Mol. Biol.,2012

3. A. Hillisch, O. Peters, C. Gege, G. Siemeister, E. Unger, B. Menzenbach, Antitumoral d-homoestra-1,3,5(10)-trien-3-yl 2-substituted sulfamates, US RE42,132 E, 2011.

4. D-ring modified estrone derivatives as novel potent inhibitors of steroid sulfatase;Fischer;Bioorg. Med. Chem.,2003

5. 17β-Hydroxysteroid dehydrogenases (17β-HSDs) as therapeutic targets: protein structures, functions, and recent progress in inhibitor development;Marchais-Oberwinkler;J. Steroid Biochem. Mol. Biol.,2011

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