MDG-1, a polysaccharide from Ophiopogon japonicus exerts hypoglycemic effects through the PI3K/Akt pathway in a diabetic KKAy mouse model

Author:

Wang Ling-Yi,Wang Yuan,Xu De-Sheng,Ruan Ke-Feng,Feng Yi,Wang Shuo

Funder

Shanghai Municipal Education Committee

National SciTech Major Special Item

Shanghai Committee of Science and Technology, China

National Natural Science Foundation of China

Dectoral Program of Higher Education

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference37 articles.

1. The inheritance of glucosuria in the KK and AY mouse;Butler;Canadian Journal oF Genetics and Cytology,1972

2. Insulin sensitivity of suppression of endogenous glucose production is the single most important determinant of glucose tolerance;Bavenholm;Diabetes,2001

3. Inhibition of glycogen synthase kinase-3 by insulin mediated by protein kinase B;Cross;Nature,1995

4. Effect of polysaccharide from Ophiopogonis tuber on blood sugar in normal and experimental diabetic mice;Chen;Chinese Journal of Modern Applied Pharmacy,1998

5. Impaired fatty acid metabolism in type 2 diabetic skeletal muscle cells is reversed by PPAR gamma agonists;Cha;American Journal of Physiology Endocrinology and Metabolism,2005

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