Gegen Qinlian decoction ameliorates TNBS-induced ulcerative colitis by regulating Th2/Th1 and Tregs/Th17 cells balance, inhibiting NLRP3 inflammasome activation and reshaping gut microbiota

Author:

Hu Yingnan,Tang Jingyi,Xie Yongfeng,Xu Wenjun,Zhu Weihan,Xia Linying,Fang Jintao,Yu Dian,Liu JingjingORCID,Zheng Zhipeng,Zhou Qiujing,Shou Qiyang,Zhang WeiORCID

Funder

National Natural Science Foundation of China

Publisher

Elsevier BV

Reference75 articles.

1. Ulcerative colitis: rapid evidence review;Adams;Am. Fam. Physician,2022

2. The TNBS-induced colitis animal model: an overview;Antoniou;Annals of medicine and surgery,2016

3. T helper 1 immunity requires complement-driven NLRP3 inflammasome activity in CD4+ T cells;Arbore;Science,2016

4. Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells;Cervantes-Barragan;Science,2017

5. PtdIns4P on dispersed trans-Golgi network mediates NLRP3 inflammasome activation;Chen;Nature,2018

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