Influences of processed rhubarbs on the activities of four CYP isozymes and the metabolism of saxagliptin in rats based on probe cocktail and pharmacokinetics approaches

Author:

Gao Jingwen,Shi Zhan,Zhu Shuzhen,Li George Q.,Yan Ru,Yao Meicun

Funder

National Natural Science Foundation of China

Science and Technology Development Fund of Macao

Publisher

Elsevier BV

Subject

Drug Discovery,Pharmacology

Reference20 articles.

1. Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK/Ay diabetic mice;Chen;Planta Medica,2009

2. Pharmacokinetic Interaction between linezolid and grapefruit juice in rats;Cuciureanu;Farmacia,2010

3. Development of a rapid UPLC-MS/MS method for quantification of saxagliptin in rat plasma and application to pharmacokinetic study;Gao;Biomedical Chromatography,2012

4. Herb–Drug interaction: effect of isopeulustrin on the metabolism and pharmacokinetics of tetramethylpyrazine by in vivo and in vitro methods;He;Drug Metabolism Reviews,2010

5. In vitro and in vivo acute antihyperglycemic effects of five selected indigenous plants from Jordan used in traditional medicine;Kasabri;Journal of Ethnopharmacology,2011

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