Investigating the possible mechanisms of pirfenidone to be targeted as a promising anti-inflammatory, anti-fibrotic, anti-oxidant, anti-apoptotic, anti-tumor, and/or anti-SARS-CoV-2

Author:

Antar Samar A.,Saleh Mohamed A.,Al-Karmalawy Ahmed A.

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference165 articles.

1. Pirfenidone is a Renal Protective Drug: Mechanisms, Signalling Pathways, and Preclinical Evidence;Bai,2021

2. Effect of pirfenidone on vascular proliferation, inflammation and fibrosis in an abdominal adhesion rat model;Hasdemir;J. Investig. Surg.,2017

3. Medicine M. PPARγ/NF-κB and TGF-β1/Smad Pathway are Involved in the Anti-fibrotic Effects of Levo-tetrahydropalmatine on Liver Fibrosis;Yu,2021

4. A Review of Pirfenidone as an Anti-Fibrotic in Idiopathic Pulmonary Fibrosis and Its Probable Role in Other Diseases;Shah,2021

5. Discovery D. From Dissection of Fibrotic Pathways to Assessment of Drug Interactions to Reduce Cardiac Fibrosis and Heart Failure;Garoffolo,2021

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