Inhibition of mTORC1/P70S6K pathway by Metformin synergistically sensitizes Acute Myeloid Leukemia to Ara-C-Reference-Cited by-同舟云学术

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Inhibition of mTORC1/P70S6K pathway by Metformin synergistically sensitizes Acute Myeloid Leukemia to Ara-C

Published:2020-02 Issue: Volume:243 Page:117276
ISSN:0024-3205
Container-title:Life Sciences
language:en
Short-container-title:Life Sciences

Author:

Yuan Fang,Cheng Cong,Xiao Feiyan,Liu Hongcai,Cao Shan,Zhou Gan

Funder

National Science and Technology Planning Project

Chinese National Science Foundation

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference44 articles.

1. Acute myeloid leukaemia;Estey;Lancet,2006

2. Association of genetic polymorphisms in genes involved in Ara-C and dNTP metabolism pathway with chemosensitivity and prognosis of adult acute myeloid leukemia (AML);Zhu;J. Transl. Med.,2018

3. Identification of prognostic subgroups among acute myeloid leukemia patients with intermediate risk cytogenetics using a flow-cytometry-based assessment of ABC-transporter function;Yuan;Leuk. Res.,2015

4. Influence of UGT1A1 polymorphisms on the outcome of acute myeloid leukemia patients treated with cytarabine-base regimens;Chen;J. Transl. Med.,2018

5. Pigneux A, Bene MC, Salmi LR, Dumas PY, Delaunay J, Bonmati C, Guieze R, Luquet I, Cornillet-Lefebvre P, Delabesse E et al: Improved Survival by Adding Lomustine to Conventional Chemotherapy for Elderly Patients With AML Without Unfavorable Cytogenetics: Results of the LAM-SA 2007 FILO Trial. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 2018:Jco2018787366, DOI: https://doi.org/10.1186/s12885-018-5002-5.

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5. Repurposing Metformin in hematologic tumor: State of art;Current Problems in Cancer;2023-08

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