Effects of Hypericum perforatum extract and its main bioactive compounds on the cytotoxicity and expression of CYP1A2 and CYP2D6 in hepatic cells

Author:

Silva Sara M.,Martinho Ana,Moreno Ivo,Silvestre Samuel,Granadeiro Luiza Breitenfeld,Alves Gilberto,Duarte Ana Paula,Domingues Fernanda,Gallardo Eugenia

Funder

Programa Operacional Regional do Centro

COMPETE

Fundação para a Ciência e Tecnologia

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference67 articles.

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3. No relevant interaction with alprazolam, caffeine, tolbutamide, and digoxin by treatment with a low-hyperforin St. John's wort extract;Arold;Planta Med.,2005

4. Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans;Bapiro;Eur. J. Clin. Pharmacol.,2005

5. Consumer use of St. John's wort: a survey on effectiveness, safety, and tolerability;Beckman;Pharmacotherapy,2000

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