Linaclotide is a potent and selective guanylate cyclase C agonist that elicits pharmacological effects locally in the gastrointestinal tract

Author:

Bryant Alexander P.,Busby Robert W.,Bartolini Wilmin P.,Cordero Etchell A.,Hannig Gerhard,Kessler Marco M.,Pierce Christine M.,Solinga Robert M.,Tobin Jenny V.,Mahajan-Miklos Shalina,Cohen Mitchell B.,Kurtz Caroline B.,Currie Mark G.

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference28 articles.

1. Different segmental transit times in patients with irritable bowel syndrome and “normal” colonic transit time: is there a correlation with symptoms?;Bouchoucha;Techniques in Coloproctology,2006

2. The molecular target of MD-1100 is guanylate cyclase C (GC-C), an apical receptor on intestinal epithelial cells;Busby;Gastroenterology,2005

3. Identification of two affinity states for low affinity receptors for Escherichia coli heat-stable enterotoxin: correlation of occupation of lower affinity state with guanylate cyclase activation;Crane;Molecular Pharmacology,1992

4. The functional gastrointestinal disorders and the Rome III process;Drossman;Gastroenterology,2006

5. Guanylate cyclase-C-mediated anti-nociceptive effects of linaclotide in rodent models of visceral pain;Eutamene;Neurogastroenterology and Motility,2009

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