Moving around the molecule: Relationship between chemical structure and in vivo activity of synthetic cannabinoids

Author:

Wiley Jenny L.,Marusich Julie A.,Huffman John W.

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference55 articles.

1. Influence of the N-1 alkyl chain length of cannabimimetic indoles upon CB(1) and CB(2) receptor binding;Aung;Drug Alcohol Depend,2000

2. Cannabinoid agonist signal transduction in rat brain: comparison of cannabinoid agonists in receptor binding, G-protein activation, and adenylyl cyclase inhibition;Breivogel;J Pharmacol Exp Ther,2000

3. Monohydroxylated metabolites of the K2 synthetic cannabinoid JWH-073 retain intermediate to high cannabinoid 1 receptor (CB1R) affinity and exhibit neutral antagonist to partial agonist activity;Brents;Biochem Pharmacol,2012

4. Synthesis and pharmacological evaluation of amino, azido, and nitrogen mustard analogues of 10-substituted cannabidiol and 11- or 12-substituted delta 8-tetrahydrocannabinol;Compton;J Med Chem,1990

5. Aminoalkylindole analogs: cannabimimetic activity of a class of compounds structurally distinct from delta 9-tetrahydrocannabinol;Compton;J Pharmacol Exp Ther,1992

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