An inhibitor of c-Jun NH2-terminal kinase, SP600125, protects mice from d-galactosamine/lipopolysaccharide-induced hepatic failure by modulating BH3-only proteins

Author:

Takamura Masaaki,Matsuda Yasunobu,Yamagiwa Satoshi,Tamura Yasushi,Honda Yutaka,Suzuki Kenji,Ichida Takafumi,Aoyagi Yutaka

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference32 articles.

1. Affinity-purified c-Jun amino-terminal protein kinase requires serine/threonine phosphorylation for activity;Adler;Journal of Biological Chemistry,1992

2. Death by association: BH3 domain-only proteins and liver injury;Baskin-Bey;American Journal of Physiology: Gastrointestinal and Liver Physiology,2005

3. Constitutive and inducible in vivo protein–DNA interactions at the tumor necrosis factor-alpha promoter in primary human T lymphocytes;Becker;Gene Expression,1999

4. The MAP kinase cascades are activated during post-ischemic liver reperfusion;Bendinelli;Federation of European Biochemical Societies Letters,1996

5. SP600125, an anthrapyrazolone inhibitor of Jun N-terminal kinase;Bennett;Proceedings of the National Academy of Sciences of the United States of America,2001

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