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Attenuation of epithelial-mesenchymal transition via SGLT2 inhibition and diabetic cataract suppression by dapagliflozin nanoparticles treatment

  • Published:2023-10 Issue: Volume:330 Page:122005
  • ISSN:0024-3205
  • Container-title:Life Sciences
  • language:en
  • Short-container-title:Life Sciences

Author:

Chen Ying-Ying,Chen Chih-Kuang,Wu Tsung-Tien,Ho Chiu-Yi,Yeh Tung-Chen,Sun Gwo-Ching,Tseng Ching-Jiunn,Cheng Pei-Wen

Funder

National Science and Technology Council

National Scientific and Technical Research Council

Kaohsiung Veterans General Hospital

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference44 articles.

1. Diabetic cataract-pathogenesis, epidemiology and treatment;Pollreisz;J. Ophthalmol.,2010

2. Aldose reductase polymorphisms, fasting blood glucose, and age-related cortical cataract;Tan;Invest. Ophthalmol. Vis. Sci.,2018

3. Advanced glycation: an important pathological event in diabetic and age related ocular disease;Stitt;Br. J. Ophthalmol.,2001

4. AKR1B1-induced epithelial-mesenchymal transition mediated by RAGE-oxidative stress in diabetic cataract lens;Wu;Antioxidants (Basel),2020

5. Epithelial-mesenchymal transdifferentiation in pediatric lens epithelial cells;Wernecke;Invest. Ophthalmol. Vis. Sci.,2018

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