Inhibition of liver alanine aminotransferase and aspartate aminotransferase by hesperidin and its aglycone hesperetin: An in vitro and in silico study

Author:

Zareei Sara,Boojar Massoud M.A.,Amanlou MassoudORCID

Funder

Kharazmi University

Tehran University of Medical Sciences

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference38 articles.

1. Effects of alanine on insulin-secreting cells: patch-clamp and single cell intracellular Ca2+ measurements;Dunne;Biochim. Biophys. Acta, Mol. Cell Res.,1990

2. Molecular mechanisms behind the biological effects of hesperidin and hesperetin for the prevention of cancer and cardiovascular diseases;Roohbakhsh;Life Sci.,2015

3. Type 2 diabetes in children is frequently associated with elevated alanine aminotransferase;Nadeau;J. Pediatr. Gastroenterol. Nutr.,2005

4. High alanine aminotransferase is associated with decreased hepatic insulin sensitivity and predicts the development of type 2 diabetes;Vozarova;Diabetes,2002

5. Chronic administration of a combination of six herbs inhibits the progression of hyperglycemia and decreases serum lipids and aspartate amino transferase activity in diabetic rats;Shafiee-Nick;Adv. Pharmacol. Sci.,2012

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