Artelastin is a cytotoxic prenylated flavone that disturbs microtubules and interferes with DNA replication in MCF-7 human breast cancer cells

Author:

Pedro Madalena,Ferreira Maria Manuel,Cidade Honorina,Kijjoa Anake,Bronze-da-Rocha Elsa,Nascimento Maria São José

Publisher

Elsevier BV

Subject

General Pharmacology, Toxicology and Pharmaceutics,General Biochemistry, Genetics and Molecular Biology,General Medicine

Reference48 articles.

1. Estrogenic and antiproliferative activities on MCF-7 Human breast cancer cells by flavonoids;Bail;Cancer Letters,1998

2. Structure-activity requirements for flavone cytotoxicity and binding to tubulin;Beutler;Journal of Medicinal Chemistry,1998

3. Flavopiridol binds to duplex DNA;Bible;Cancer Research,2000

4. Flavopiridol: a cytotoxic flavone that induces cell death in noncycling A549 human lung carcinoma cells;Bible;Cancer Research,1996

5. Selected novel flavones inhibit the DNA relegation step of eukaryotic topoisomersase I;Boege;The Journal of Biological Chemistry,1996

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