The antiepileptic drug AWD 131–138 stimulates different recombinant isoforms of the GABAA receptor through the benzodiazepine binding site-Reference-Cited by-同舟云学术

The antiepileptic drug AWD 131–138 stimulates different recombinant isoforms of the GABAA receptor through the benzodiazepine binding site

Published:1998-04 Issue:2 Volume:245 Page:85-88
ISSN:0304-3940
Container-title:Neuroscience Letters
language:en
Short-container-title:Neuroscience Letters

Author:

Sigel Erwin,Baur Roland,Netzer Rainer,Rundfeldt Chris

Publisher

Elsevier BV

Subject

General Neuroscience

Reference20 articles.

1. GABAA receptor needs two homologous domains of the β-subunit for activation by GABA but not by pentobarbital;Amin;Nature,1993

2. A point mutation in the γ subunit of α1β2γ2 GABAA receptors alters specificity for ligands of the benzodiazepine binding site;Buhr;Proc. Natl. Acad. Sci. USA,1997

3. Point mutations of the α1β2γ2 GABAA receptor affecting modulation of the channel by ligands of the benzodiazepine binding site;Buhr;Mol. Pharmacol.,1996

4. Subtle changes in residue 77 of the γ subunit of α1β2γ2 GABAA receptors drastically alter the affinity for ligands of the benzodiazepine binding site;Buhr;J. Biol. Chem.,1997

5. Residues at positions 206 and 209 of the α1 subunit of γ-aminobutyric acidA receptors influence affinities for benzodiazepine binding site ligands;Buhr;Mol. Pharmacol.,1997

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