Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)-Reference-Cited by-同舟云学术

Hitting the right spot: Mechanism of action of OPB-31121, a novel and potent inhibitor of the Signal Transducer and Activator of Transcription 3 (STAT3)

Published:2015-03-05 Issue:6 Volume:9 Page:1194-1206
ISSN:1574-7891
Container-title:Molecular Oncology
language:en
Short-container-title:

Author:

Brambilla Lara,Genini Davide,Laurini Erik,Merulla Jessica,Perez Laurent,Fermeglia Maurizio,Carbone Giuseppina M.,Pricl Sabrina,Catapano Carlo V.

Funder

Otsuka Pharmaceuticals

Ticino Foundation for Cancer Research

Foundation Virginia Boeger

Publisher

Wiley

Subject

Cancer Research,Genetics,Molecular Medicine,General Medicine,Oncology

Link

http://onlinelibrary.wiley.com/wol1/doi/10.1016/j.molonc.2015.02.012/fullpdf

Reference54 articles.

1. Three-dimensional structure of the Stat3beta homodimer bound to DNA;Becker;Nature,1998

2. Phase 1, open-label, dose-escalation, and pharmacokinetic study of STAT3 inhibitor OPB-31121 in subjects with advanced solid tumors;Bendell;Cancer Chemother. Pharmacol.,2014

3. Targeting signal transducer and activator of transcription signaling pathway in leukemias;Benekli;J. Clin. Oncol.,2009

4. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis;Chan;J. Clin. Invest.,2004

5. Interleukin-6 regulation of prostate cancer cell growth;Culig;J. Cell Biochem.,2005

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