Pyruvate kinase M2, but not M1, allele maintains immature metabolic states of murine embryonic stem cells

Author:

Konno MasamitsuORCID,Ishii Hideshi,Koseki Jun,Tanuma Nobuhiro,Nishida Naohiro,Kawamoto Koichi,Nishimura Tatsunori,Nakata Asuka,Matsui Hidetoshi,Noguchi Kozou,Ozaki Miyuki,Noguchi Yuko,Shima Hiroshi,Gotoh Noriko,Nagano Hiroaki,Doki Yuichiro,Mori Masaki

Funder

Ministry of Education, Culture, Sports, Science, and Technology

Ministry of Health, Labor, and Welfare

National Institute of Biomedical Innovation

Osaka University Drug Discovery Funds, Japan

Kobayashi Cancer Research Foundation

Princess Takamatsu Cancer Research Fund

Takeda Science and Medical Research Foundation

Suzuken Memorial Foundation

Yasuda Medical Foundation

Pancreas Research Foundation of Japan

Chugai Co., Ltd.

Yakult Honsha Co., Ltd

Merck Co., Ltd.

Unitech Co., Ltd.

EBM Research Center Inc.

Taiho Therapeutic Co., Ltd.

Publisher

Elsevier BV

Subject

Developmental Biology,Biomedical Engineering,Biomaterials

Reference24 articles.

1. Electrophoretic and kinetic studies of mutant erythrocyte pyruvate kinases;Nakashima;Blood,1974

2. Crystallization, characterization and metabolic regulation of two types of pyruvate kinase isolated from rat tissues;Tanaka;J Biochem,1967

3. Pyruvate kinase isozymes from rat;Imamura;Methods Enzymol,1982

4. Pyruvate kinase type M2 and its role in tumor growth and spreading;Mazurek;Semin Cancer Biol,2005

5. The M1- and M2-type isozymes of rat pyruvate kinase are produced from the same gene by alternative RNA splicing;Noguchi;J Biol Chem,1986

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