The Ink4a Tumor Suppressor Gene Product, p19Arf, Interacts with MDM2 and Neutralizes MDM2's Inhibition of p53

Author:

Pomerantz Jason,Schreiber-Agus Nicole,Liégeois Nanette J,Silverman Adam,Alland Leila,Chin Lynda,Potes Jason,Chen Ken,Orlow Irene,Lee Han-Woong,Cordon-Cardo Carlos,DePinho Ronald A

Publisher

Elsevier BV

Subject

General Biochemistry, Genetics and Molecular Biology

Reference67 articles.

1. Role for N-CoR and histone deacetylase in Sin3-mediated transcriptional repression;Alland;Nature,1997

2. Regulation of mdm2 expression by p53;Barak;Genes Dev.,1994

3. The p16-cyclin D/Cdk4-pRb pathway as a functional unit frequently altered in melanoma pathogenesis;Bartkova;Cancer Res.,1996

4. Preferential loss of expression of p16INK4a rather than p19ARF in breast cancer;Brenner;Clin. Cancer Res.,1996

5. The tumor suppressor p53 and the oncoprotein simian virus 40 T antigen bind to overlapping domains on the MDM2 protein;Brown;Mol. Cell. Biol.,1993

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