Differentiating the Effect of an Opioid Agonist on Cardiac Repolarization From µ-Receptor–mediated, Indirect Effects on the QT Interval: A Randomized, 3-way Crossover Study in Healthy Subjects

Author:

Darpo Borje,Zhou Meijian,Bai Stephen A.,Ferber Georg,Xiang Qinfang,Finn Andrew

Publisher

Elsevier BV

Subject

Pharmacology (medical),Pharmacology

Reference27 articles.

1. Influence of opioid agonists on cardiac human ether-a-go-go-related gene K(+) currents;Katchman;J Pharmacol Exp Ther,2002

2. Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development;Redfern;Cardiovasc Res,2003

3. Butrans. Clinical Pharmacology and Biopharmaceutics Review. http://www.accessdata.fda.gov/drugsatfda_docs/nda/2010/021306Orig1s000ClinPharmR.pdf. 2014.

4. Butrans. US label July 2013. http://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021306s016lbl.pdf. 2013.

5. ICH E14 Questions & Answers. http://www.ich.org/fileadmin/Public_Web_Site/ICH_Products/Guidelines/Efficacy/E14/E14_QAs_R2_Step4.pdf . 2014.

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