Alzheimer's disease in Down syndrome: An overlooked population for prevention trials

Author:

Strydom André1234,Coppus Antonia56,Blesa Rafael78,Danek Adrian9,Fortea Juan7810,Hardy John31112,Levin Johannes913,Nuebling Georg9,Rebillat Anne‐Sophie14,Ritchie Craig15,Duijn Cornelia16,Zaman Shahid1718,Zetterberg Henrik11192021

Affiliation:

1. Department of Forensic and Neurodevelopmental SciencesInstitute of Psychiatry, Psychology & Neuroscience, Kings College LondonLondonUK

2. Division of PsychiatryUniversity Collee LondonLondonUK

3. The London Down Syndrome Consortium (LonDownS)UK

4. South London and Maudsley NHS Foundation TrustLondonUK

5. DichterbijCenter for Intellectual DisabilitiesGennepthe Netherlands

6. Department of Primary and Community CareRadboud University Medical CenterNijmegenthe Netherlands

7. Memory Unit, Department of NeurologyHospital de la Santa Creu i Sant Pau‐ Biomedical Research Institute Sant Pau‐Universitat Autònoma de BarcelonaBarcelonaSpain

8. Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, CIBERNEDSpain

9. Department of NeurologyLudwig‐Maximilians‐Universität MünchenMunichGermany

10. Barcelona Down Medical Center, Fundació Catalana de Síndrome de DownBarcelonaSpain

11. Department of Molecular NeuroscienceUCL Institute of NeurologyLondonUK

12. Reta Lila Weston Institute, Institute of Neurology, University College LondonLondonUK

13. German Center for Neurodegenerative Diseases (DZNE) site MunichMunichGermany

14. Institut Jérôme LejeuneParisFrance

15. Centre for Clinical Brain Sciences, Dementia Prevention Research Group, University of Edinburgh

16. Department of EpidemiologyErasmus Medical CentreRotterdamthe Netherlands

17. Cambridge Intellectual & Developmental Disabilities Research GroupDepartment of PsychiatryUniversity of CambridgeCambridgeUK

18. Cambridgeshire & Peterborough NHS Foundation Trust (CBFT), Fulbourn HospitalCambridgeUK

19. UK Dementia Research Institute at UCLLondonUK

20. Institute of Neuroscience and PhysiologyDepartment of Psychiatry and Neurochemistrythe Sahlgrenska Academy at the University of GothenburgMölndalSweden

21. Clinical Neurochemistry Laboratory, Sahlgrenska University HospitalMölndalSweden

Funder

Wellcome Trust

Publisher

Wiley

Subject

Psychiatry and Mental health,Neurology (clinical)

Reference51 articles.

1. Preclinical Alzheimer's disease: Definition, natural history, and diagnostic criteria

2. Recommended cognitive outcomes in preclinical Alzheimer's disease: Consensus statement from the European Prevention of Alzheimer's Dementia project

3. The DIAN‐TU Next Generation Alzheimer's prevention trial: Adaptive design and disease progression model

4. European Medicines Agency. Guideline on the clinical investigation of medicines for the treatment of Alzheimer's disease 2018.

5. U.S. Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) Center for Biologics Evaluation and Research (CBER). Early Alzheimer's Disease: Developing Drugs for Treatment Guidance for Industry 2018.

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